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Sheets of Virus Generate Electricity when Squished

Pressing a virus-filled device can generate power. (The gloves protect the virus, which only infects bacteria, from us.)

Squishing a stack of virus sheets generates enough electricity to power a small liquid crystal display. With increased power output, these virus films might one day use the beating of your heart to power a pacemaker, the researchers behind them say.

Piezoelectric materials build up charge when pushed or squeezed. These materials may be familiar to you: they generate the spark in a gas lighter, and motors powered by such materials vibrate some cell phones. Piezoelectric materials made of metals or polymers require large inputs of energy to build up a charge. Bone, DNA, and protein fibers are weakly piezoelectric, but it’s hard to efficiently organize these materials on a large scale to yield electricity.

To handle this organizational issue, Seung-Wuk Lee, of the University of California in Berkeley and the Lawrence Berkeley National Laboratory, and his colleagues looked for a biomaterial that had intrinsic order and was easy to make. They settled on the M13 bacteriophage, a rod-shaped virus that only infects bacteria. One bacterium can produce one million copies of the virus within four hours, so starting material isn't a problem. And the virus neatly arranges itself in stacked rows when spread on a surface.

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Synthetic DNA substitute gets its own enzymes, undergoes evolution

On Earth, all life is dependent upon the nucleic acids, DNA and RNA. But researchers Including those who are wondering how to detect life somewhere other than Earth, have wondered whether other information-bearing polymers might also serve this purpose. Is there something special about DNA and RNA, or did they just happen to be the first things that work? The answer to that question would not only have implications for the origin of life on Earth and elsewhere, but it might have practical uses.

Researchers have now taken a major step towards showing that alternatives can actually work as genetic material. They replaced a standard part of nucleic acids with a number of chemical relatives, and found out that they all could work. Sequence information could be shuttled back and forth between these artificial molecules and DNA, and the synthetic materials could even undergo the sort of molecular evolution that has been demonstrated using DNA and RNA.

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Crowd-sourced biotech: gamers tweak protein, give it big activity boost

"Citizen science" is a recent movement to get interested members of the public involved in scientific research. Participants—who may or may not have scientific training—can perform tasks that can't be automated well, such as analyzing images. One of the most successful citizen science projects has been FoldIt, a game based on the biochemistry of how proteins form structures in three dimensions.

When asked to figure out the likely structure of a protein, FoldIt players have done remarkably well, in some cases surpassing the best algorithms devised by computer scientists. But until recently, all they've been asked to do is figure out how existing proteins fold. That has now changed; the people behind the FoldIt project have added tools that allow players to engineer new variants of an old protein. Once again, the gamers have come through, figuring out changes that dramatically improve the protein's activity.

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How did molecular machines evolve? Researchers resurrect lost proteins to find out

Our cells are filled with complexes that can contain dozens of proteins, all with precise interactions that ensure the complex comes together and functions in a consistent manner. These complexes, which can contain dozens of individual proteins, often have activities that mimic those of human-produced equipment, and have earned the nickname "molecular machines" accordingly.

If a molecular machine requires so many precisely positioned parts to function, how could it possibly evolve? That question has been part of a populist attack on evolution but, contrary to its proponents, scientists have a number of ideas about the evolution of this machinery. It's just that those ideas can be very hard to test, since we can't go back in time and look at the predecessors to today's machines.

Advances in DNA sequencing, however, have allowed us to calculate what the earlier proteins must have looked like. And scientists have now started to engineer DNA sequences that "resurrect" these long dead proteins, and examine how they function. In the latest work of this sort, a team has resurrected parts of an ancient molecular machine, and shown how some of its specialized protein components evolved.

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Naked mole rats feel no pain due to acid

African naked mole rats never cease to amaze. Not only are they exceedingly ugly, but they are the longest living rodents. Moreover, none have ever been observed to get cancer. And they are the only known vertebrates that are not bothered by acid. A report in this week’s Science explains the molecular basis underlying this acid insensitivity, and suggests that it might be an adaptation to their oxygen-poor living conditions..

Acid causes pain by activating nociceptors, proton-triggered ion channels that activate neurons. This recent study compared acid receptors from naked mole rats and mice, and found that they were not all that different. Similar numbers of each receptor were found in the respective animals, and acid evoked similar levels of current through them.

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